שטודיע: מענטשען וואס הבאבן שוין געהאט קאוויד זענען מער באשיצט ווי וואקסינירטע

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די אחראים: זייער נייגעריג,אחראי,thefact

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זיך איינגעשריבן אום: מאנטאג דעצעמבער 05, 2016 5:11 pm

שטודיע: מענטשען וואס הבאבן שוין געהאט קאוויד זענען מער באשיצט ווי וואקסינירטע

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פונעם א.ג פרעסטיזשפולע the lancet.


In The Lancet, Victoria J Hall and colleagues7 report the effectiveness of BNT162b2 against SARS‑CoV-2 infection from the observational SIREN (SARS‑CoV-2 Immunity and REinfection EvaluatioN) study, a rigorous, prospective, longitudinal cohort study of 23 324 health-care workers (HCWs) in hospitals in England. Most participants were female (84%), of white (88%) or Asian (7%) ethnicity, and in a patient-facing role (86%), with a median age of 46·1 years (IQR 36·0–54·1). The SIREN study was originally designed to assess the effect of previous SARS-CoV-2 infection against reinfection.8 Participants regularly reported symptoms and underwent swabbing with PCR testing every 14 days and monthly serology, regardless of symptoms. When COVID-19 vaccines were rolled out in the UK and HCWs were prioritised, the SIREN study provided a platform to rapidly assess effectiveness against SARS-CoV-2 infection and COVID-19 disease by linking to electronic vaccination and test result records in addition to self-report questionnaires.
Hall and colleagues report that BNT162b2's effectiveness against asymptomatic or symptomatic infection was 70% (95% CI 55–85) 21 days after a single dose and 85% (74–96) 7 days after two doses in SIREN. With the intense surveillance protocol, the risk of missing an asymptomatic infection was small. Therefore, SIREN provides robust real-world estimates of vaccine protection against infection, a crucial component to understanding how vaccination can curtail transmission.
These results will help public health experts and policy makers to refine targets for achieving the level of population immunity through vaccination that would be needed to stop widespread transmission. Although the precise value and even the possibility of herd immunity to SARS-CoV-2 is debatable, most epidemiologists think the threshold is about 70% protected by vaccination or previous infection. To achieve that in the absence of naturally acquired immunity, nearly 100% of the population would need to be vaccinated with one dose or about 80% with two doses (based on an effectiveness against infection of 70% and 85%, respectively, from SIREN). Accordingly, a one-dose strategy might be best for averting the most deaths, but higher population immunity to quell transmission will require a full course of two doses. Reduction of transmission by vaccination for population immunity will mandate high coverage rates in the entire population, independent of age, -, or ethnicity differences.
There are two more insights from SIREN with implications for population immunity. First, of vaccinated participants who were infected with SARS‑CoV‑2, 40% reported typical COVID-19 symptoms compared with 63% in the unvaccinated group. In other words, vaccinees were less likely to progress to symptoms once infected, which is the second mechanism of vaccine protection. Presence of symptoms has a complex relationship with SARS‑CoV‑2 transmission, since asymptomatically infected people play a key role in spread.9 However, since breakthrough cases among vaccinated individuals shed virus at lower levels, they are probably less infectious than unvaccinated individuals are.3 Second, in this study population, participants who previously had COVID-19 were less likely to be vaccinated. But this positive cohort still had 90% (95% CI 88–92) protection against subsequent infection, independent of vaccination, which is similar to findings from a large study in Denmark.10 Current guidelines call for previously infected individuals to be vaccinated and we do not advocate for a change to that policy. But, if previously infected individuals have high levels of immunity while previously uninfected individuals are prioritised to be vaccinated, the vaccination programme will be more efficient at achieving population immunity than one immunising the population at random.
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זיך איינגעשריבן אום: מאנטאג דעצעמבער 05, 2016 5:11 pm

Re: שטודיע: מענטשען וואס הבאבן שוין געהאט קאוויד זענען מער באשיצט ווי וואקסינירטע

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ער פירט אויס אז ער איז חלילה נישט מהרהר אויף די אלע "סייענטיסטען" וואס זאגן אז מען זאל יא נעמען, אבער פאר א פיצקעלע סניף קען מען עס יא נעמען "לולי דמסתפי" . שיגענע וועלט.

Current guidelines call for previously infected individuals to be vaccinated and we do not advocate for a change to that policy. But, if previously infected individuals have high levels of immunity while previously uninfected individuals are prioritised to be vaccinated, the vaccination programme will be more efficient at achieving population immunity than one immunising the population at random
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